Dasision study cml healthcare

SPRYCEL (dasatinib) for Healthcare Professionals

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SPRYCEL ® (dasatinib) is indicated for the treatment of adults with: Newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase; Chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to …

SPRYCEL (dasatinib) for Healthcare Professionals

Study Design for Newly Diagnosed Patients | SPRYCEL-hcp.com

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Head-to-Head Trial Design: SPRYCEL ® (dasatinib) vs Imatinib. Return to: Efficacy . DASISION Trial: SPRYCEL vs Imatinib Study in Treatment-Naïve CP Ph+ CML Adult Patients 1,2. Primary endpoint: cCCyR a by 12 months 2 Select secondary endpoints included: MMR b at any time, time to MMR, and time to cCCyR 2 Patients with a history of cardiac disease were included in this study, except those …

Study Design for Newly Diagnosed Patients | SPRYCEL-hcp.com

Be Chronic Myeloid Leukemia (CML) Informed

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Data come from a retrospective cohort study of patients newly diagnosed with CML in the US who were initiating first-line TKI therapy (N=1431). 5 This study is subject to several limitations due to the data sources. The data come from a commercial insurance database, which …

Be Chronic Myeloid Leukemia (CML) Informed

Sprycel Shows Promise as a First Line Therapy - Chronic ...

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1/17/2011 · The results from the 18 month Phase III DASISION study look very promising for Sprycel as an effective first-line therapy treatment. The DASISION study enrolled 519 newly diagnosed chronic phase ph+ Chronic Myeloid Leukemia patients. The trial provided 259 randomized patients with 100 mg of Sprycel once daily, and the other 260 patients received 400mg of imatinib once daily.

Sprycel Shows Promise as a First Line Therapy - Chronic ...

Sprycel Shows Promise as First Line Therapy for CML ...

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The results from the 18 month Phase III DASISION study look very promising for Sprycel as an effective first-line therapy treatment. The DASISION study enrolled 519 newly diagnosed chronic phase ph+ Chronic Myeloid Leukemia patients. The trial provided 259 randomized patients with 100 mg of Sprycel once daily, and the other 260 patients received 400mg of imatinib once daily.

Sprycel Shows Promise as First Line Therapy for CML ...

FDA Approves SPRYCEL® (dasatinib) as Treatment for Adult ...

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10/28/2010 · About the DASISION Study. DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CP-CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 mg taken once daily vs. imatinib 400 mg taken once daily, in …

FDA Approves SPRYCEL® (dasatinib) as Treatment for Adult ...

Efficacy and safety of dasatinib versus imatinib in the ...

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In the phase 3 DASISION trial (Dasatinib Versus Imatinib Study In Treatment-Naive Chronic Myeloid Leukemia), patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) were randomized to receive first-line treatment with either dasatinib 100 mg once daily (QD) or …

Efficacy and safety of dasatinib versus imatinib in the ...

Follow-Up Results from Study Comparing SPRYCEL® (dasatinib ...

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12/6/2010 · About the DASISION Study. DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CP-CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 mg taken once daily vs. imatinib 400 mg taken once daily, in the treatment of …

Follow-Up Results from Study Comparing SPRYCEL® (dasatinib ...

CML Updates: Defining MMR and Results of the DASISION Trial

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In his talk, “Final study results of the phase 3 dasatinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) trial (DASISION, CA180-056),” he reported the ...

CML Updates: Defining MMR and Results of the DASISION Trial

CML Updates: Defining MMR and Results of the DASISION Trial

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1/19/2015 · Healthcare Costs in Need of Solutions: Experts at ASH Agree ... presented results from the DASISION trial. In his talk, “Final Study Results of the Phase 3 Dasatinib Versus Imatinib in Newly ...

CML Updates: Defining MMR and Results of the DASISION Trial

Long-term dasatinib findings support first-line use in CML

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6/15/2016 · Final DASISION study findings confirm dasatinib to be an effective, long-term treatment for patients with a new diagnosis of chronic phase-chronic myeloid leukaemia (CP-CML). After 5 …

Long-term dasatinib findings support first-line use in CML

Imatinib is still recommended for frontline therapy for CML

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Data from the IRIS trial and CML Study IV, each with more than 10 years of follow-up, established ... The ENESTnd, DASISION, and BFORE trials were the primary registration trials for the frontline ... healthcare system,cost-effectiveness analysescontinue toshow

Imatinib is still recommended for frontline therapy for CML

Lymphocytosis after treatment with dasatinib in chronic ...

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5/1/2016 · The proliferation of clonal cytotoxic T‐cells or natural killer cells has been observed after dasatinib treatment in small studies of patients with chronic myeloid leukemia (CML). (a,b) The treatment of a woman who had imatinib‐resistant, blast‐phase chronic myeloid leukemia with splenomegaly ...

Lymphocytosis after treatment with dasatinib in chronic ...

First-line treatment for chronic myeloid leukemia ...

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11/26/2010 · Imatinib, a tyrosine kinase inhibitor (TKI) of BCR-ABL, was the standard first-line therapy for chronic myeloid leukemia (CML) for almost 10 years. Dasatinib and nilotinib, two newer drugs with higher potency than imatinib against BCR-ABL and activity against most imatinib-resistant BCR-ABL mutations, have each shown superior efficacy compared with imatinib for first-line treatment of chronic ...

First-line treatment for chronic myeloid leukemia ...

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

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DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 mg taken once daily with no food restrictions ...

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

Dasatinib dose management for the treatment of chronic ...

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1/25/2018 · The CA180‐056 DASISION trial (Dasatinib Versus Imatinib Study in Treatment‐Naïve Chronic Myeloid Leukemia Patients) was a study of newly diagnosed patients with CML‐CP who received dasatinib at a dose of 100 mg once daily or imatinib at a dose of 400 mg once daily for a minimum of 5 years. 10 At the end of DASISION, dasatinib at a dose ...

Dasatinib dose management for the treatment of chronic ...

Lymphocytosis after treatment with dasatinib in chronic ...

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Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity. Authors. Charles A. Schiffer MD, ... CML-AP and CML-MBP, were no longer receiving dasatinib at that time (median on-treatment follow-up, 6.1 months). In the DASISION study, lymphocytosis was observed in 35% and 8% of dasatinib- and ...

Lymphocytosis after treatment with dasatinib in chronic ...

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

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This study, known as DASISION, compared the investigational use of SPRYCEL versus Gleevec as a first-line treatment for patients with chronic phase chronic myeloid leukemia (CML-CP).

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

BCR-ABL1 mutation development during first-line treatment ...

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6/29/2015 · BCR-ABL1 mutations are a common, well-characterized mechanism of resistance to imatinib as first-line treatment of chronic myeloid leukemia in chronic phase (CML …

BCR-ABL1 mutation development during first-line treatment ...

Lymphocytosis after treatment with dasatinib in chronic ...

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Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity ... low-up, 6.1 months). In the DASISION study, lympho- ... UDG Healthcare plc, funded by ...

Lymphocytosis after treatment with dasatinib in chronic ...

Final 5-Year Study Results of DASISION: The Dasatinib ...

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Purpose: We report the 5-year analysis from the phase III Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients (DASISION) trial, evaluating long-t

Final 5-Year Study Results of DASISION: The Dasatinib ...
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